Report: The effects of topical pleurotus tuberregium (PT) aqueous extract on intraocular pressure in monkeys.

Report: The effects of topical pleurotus tuberregium (PT) aqueous extract on intraocular pressure in monkeys.

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Purpose

In earlier experiments in YELLOW DOCK Nigeria, aqueous extract of Pleurotus tuber-regium (PT) had been shown to lower intra ocular pressure (IOP) in a feline model.The aim of the current study was to determine whether PT had the same or a similar IOP-lowering effect in ocularly normal non-human primates.

Methods

Four monkeys were treated twice daily for 4 days with 2 x 20 μl drops of 50 mg/ml PT (pH = 4.3).The monkeys were sedated with 5-10 mg/kg ketamine HCl IM.

PT was administered to the right eye and BSS to the left eye.Baseline IOP was measured just prior to beginning treatment, and on day 5 before treatment and then hourly for 3 hours, beginning 1 hour after treatment.SLEs were performed at baseline and on day 5 pre- and 3 hours post-treatment.

Results

There was no significant difference between IOP in Toys treated vs control eyes in the protocol.There were no adverse effects or toxicity as seen by SLE.

Conclusions

The inability of the extract to lower IOP in monkeys, in contrast to ocular hypertensive cats in an earlier study, could be due to species differences or duration of treatment.Since no adverse effects were observed in the monkeys, further studies with varying durations and dosages are recommended.

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